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Digestive Enzyme

It’s time you put the enjoyment back in eating your favorite foods!

Digestive Enzyme

It’s time you put the enjoyment back in eating your favorite foods!

Nucific Digestive Enzyme helps your body smoothly and more efficiently process the foods you eat — so you can enjoy more of your favorite foods with less gastric distress… while getting the most from their vital nutrients.*

*All individuals are unique. Your results can and will vary.

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Made With You In Mind

MFG in
the USA

GMP Certified

Made With You In Mind

MFG in
the USA

How It Works

Supports Smoother Digestion*

Our proprietary blend of 16 powerful digestive enzymes helps you break down every type of food, so your body can get the maximum nutritional benefits from those foods, while enjoying smoother, more comfortable digestion.

Amylase, Diastase, Glucoamylase, Beta-Glucanase, and 4 other enzymes help to gently break down carbs, grains, and starches, then convert them into usable energy.

Bacterial Protease, Fungal Protease, and Acid Protease break down proteins, which are critical for a healthy body, including your immune system, tissue, muscle, skin, hair, and nails.

Lactase helps break down dairy products, so you can experience less digestive distress.

Lipase breaks down fats, and helps promote healthy organ function.

Reduces Gas & Bloating*

Alpha-Galactosidase helps break down gas-producing carbohydrates, easing digestive discomfort and allowing for smooth digestion.

Hemicellulase helps your body digest the soluble fiber found in plants. These valuable prebiotic fibers help support your gut’s healthy gut bacteria.

Cellulase breaks down cellulose (plant fiber), which eases digestive discomfort and helps free the nutrients found in fruits and vegetables so your body can absorb them.

*All individuals are unique. Your results can and will vary.

Learn More

How Many Bottles Do You Recommend I Order?

Many of our customers enjoy the discounted 3-bottle option to ensure they’ve got plenty of Digestive Enzyme on hand. If you plan on sharing with your family, we suggest purchasing the 6-bottle discount instead.

What's In Digestive Enzyme?

90 Capsules

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 90

Amount Per Serving % Daily
Amylase 20,000 DU **
Diastase 20,000 DP **
Bacterial Protease 50,000 HUT **
Glucoamylase 50 AGU **
Fungal Protease 20,000 HUT **
Alpha-Galactosidase 500 GALU **
Lactase 750 ALU* **
Cellulase 1,500 CU **
Beta-Glucanase 50 BGU **
Lipase 2,400 FIP **
Xylanase 1,000 XU **
Pectinase 50 endo-PGU **
Acid Protease 20 SAPU **
Phytase 10 FTU **
Invertase 500 SU **
Hemicellulase 500 HCU **

** Daily Value (DV) not established

Is it gentle on the digestive system?

Digestive Enzyme is made from 100% gluten-free, allergen-free capsules and is designed to gently work with your body to help enhance your digestion. Nevertheless, always consult with a doctor before beginning any new supplements.

How do I take Digestive Enzyme?

For optimal results, please take 1-2 Digestive Enzyme capsules with a full glass of water with each meal. Do not exceed 6 capsules per day. We suggest that you start taking one capsule with each meal and wait to experience results before deciding to take two per meal.

What will happen if I miss a day?

If you miss a meal or a day, simply resume your Digestive Enzyme regimen at the following meal. You don’t need to take extra capsules to make up for the ones you’ve missed.

When can I experience results?

Everyone’s system is different, so we suggest waiting 60-90 days to experience the full benefits of Digestive Enzyme, including more comfortable digestion, reduced gas and bloating and more. It can take 1-2 months for the enzymes to fully populate your system, but if you keep up your regimen and eat balanced, nutritious meals, you can experience results.

Where to buy Digestive Enzyme: Is it online or in stores?

Digestive Enzyme is currently available for purchase online! Listings from 3rd party websites will not include our 90-day money-back guarantee.

*All individuals are unique. Your results can and will vary.

Suggested Use

Take 1 capsule with each meal. You may increase dosage to 2 capsules per meal. You should take at least 3 capsules per day. Do not take more than 6 capsules per day.


4.8 49 Reviews

*All individuals are unique. Your results can and will vary.


Apr 9 2024

Look this!

Very gassy at first but then everything comes together and my gut health is under control using Nucific products ❤️Thanks Amy!


Apr 8 2024


I have been using Bio X 4 for quite a few years. It settles my digestive issues and is particularly helpful when it comes to bloating. I use it as directed, 1 before each meal. It works great! It’s a reliable product.


Apr 1 2024

Nucific Digestive Enzyme

I have been using this for only a couple of weeks at most but I have less stomach discomfort and upset. I still have some gas but don’t feel as bloated. I am pleased and hope that I have more good stomach bacteria.


Jan 16 2024

Feel better

I have lost a few pounds and feel better, with better digestive health. I am able to fit into my pants much better.


May 24 2023

Digestive Enzyme works for me!

I take A LOT of probiotics on a daily basis – the Bio-X4, the Nighttime Slimming Complex, the Deep Cell Activator, and the Pro Body Trim. But when I began the Digestive Enzyme, everything began to be more efficient! My digestion is EXCELLENT! Thank you, Dr. Lee!


Apr 5 2023

Digestive Enzymes

Since I have been taking these supplements, I have noticed a drastic change in my digestive system. When I remember to take them ( and I say “remember”, because I right away notice the difference when I don’t take them), I feel lighter. I don’t have bloating, stomach pains or hard stool. Everything runs smoothly. I will say that in the beginning I had gas that didn’t smell so great, but after taking it consistently, it went away. It feels great not to have to worry about how I will feel after I eat.


Feb 26 2023


I simply love my Bio-X4 I have experienced great results that everyone around me have noticed and everyone’s been asking me what I’ve been doing and I am proud to tell them about the over all health benefits of this product. I am a proud customer and will continue to buy more of Dr lee’s product she is truly wonderful and I back her up completely.


Feb 24 2023

Good Product

Product is great probiotic However I do not feel it helped much with weight loss.


Jan 6 2023

Nucific products are working


The probiotic supplement definitely helps maintain regularity. Achieving a healthy gut microbiome was the primary reason I purchased Nucific’s products. The digestive enzyme appears to have helped and the BioX4 has definitely decreased my food cravings. I expect that these products combined with my exercise program will promote the weight loss needed.


Jun 10 2022

Digestive enzyme

I’ve been using this product in combination with Bio-X4 and am having great success. I was experiencing bloating after eating or drinking even a small portion. Bio-X4 relieved the bloating and the Digestive Enzyme has helped to level everything out. Since starting the combination I’m feeling much better and my energy level is much higher than prior to using these products.

*All individuals are unique. Your results can and will vary.

4.8 out of 5
4.8 OUT OF 5

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  2. Antony N, Balachandran S, Mohanan PV. Immobilization of diastase α-amylase on nano zinc oxide. Food Chem. 2016;211:624-630. doi:10.1016/j.foodchem.2016.05.049
  3. Kumar P, Satyanarayana T. Microbial glucoamylases: characteristics and applications. Crit Rev Biotechnol. 2009;29(3):225-255. doi:10.1080/07388550903136076
  4. Celestino KR, Cunha RB, Felix CR. Characterization of a beta-glucanase produced by Rhizopus microsporus var. microsporus, and its potential for application in the brewing industry. BMC Biochem. 2006;7:23. Published 2006 Dec 5. doi:10.1186/1471-2091-7-23
  5. López-Otín C, Bond JS. Proteases: multifunctional enzymes in life and disease. J Biol Chem. 2008;283(45):30433-30437. doi:10.1074/jbc.R800035200
  6. Dajani EZ, Dajani NE, Shahwan TG. Over-the-Counter Drugs. In: Encyclopedia of Gastroenterology. Elsevier; 2004.
  7. Pirahanchi Y, Sharma S. Biochemistry, Lipase. [Updated 2021 Jul 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from:
  8. Di Stefano M, Miceli E, Gotti S, Missanelli A, Mazzocchi S, Corazza GR. The effect of oral alpha-galactosidase on intestinal gas production and gas-related symptoms. Dig Dis Sci. 2007;52(1):78-83. doi:10.1007/s10620-006-9296-9
  9. Yi Y. Tiny Bugs Play Big Role: Microorganisms’ Contribution to Biofuel Production. In: Advances in 2nd Generation of Bioethanol Production. Woodhead Publishing; 2021.
  10. Image gallery gateway. Image: New Cellulase Enzymes Dramatically Reduce Costs of Plant Biomass Breakdown: R&D 100 Award.

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